This was really driving me nuts and almost caused me to completely switch to Chrome which I use from time to time. Here’s how I resolved the problem. As soon as I would launch IE 8, the Data Execution Prevention (DEP) dialogue box would pop up. I would hit OK and then it would shut down IE 8. I tried disabling DEP for Internet Explorer but this still happened at first about 50% and then almost 100% of the time. I even tried uninstalling the MSJVM. None of this helped.
I noticed that if I did not clear the DEP dialogue, I could move it out of the way and open another tab in IE8. I could also select Tools, Manage Add-Ons. I then disabled most of the add-ons (ones I didn’t really need or didn’t even know were there). That did the trick.
Hopefully this will help any other unfortunate souls out there with this very annoying problem.

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July 5, 2009 at 3:30 am
Dude thanks so much I thought it was IE8 that just sucked causing all the problems and I too went through all that. My homepage was youtube.com so everytime I tried to view videos it would eventually fail on me. I’ll try out your solution since DEP can’t be removed. Thanks again.
July 23, 2009 at 11:44 pm
Thanks much for this post! I’m having the exact problem you describe and will try your fix just as soon as the computer with the problem finishes reboot. :-p
July 30, 2009 at 3:07 pm
Okay…. fixed!
control panel/internet options/advanced/resey inertnet explorer settings
Part of the process disables addons… job done!
August 14, 2009 at 6:42 pm
Thank you, NickV! This worked, and if I can do it, anyone can – I’m an accountant, not an IT wizard! ;-)
I am copying your solution here so the next frustrated non-coomputer person will see it before they stop scrolling down the list.
Thank again,
Gladiam
NickV said:
Okay…. fixed!
control panel/internet options/advanced/resey inertnet explorer settings
Part of the process disables addons… job done!
September 12, 2009 at 12:36 pm
Thanks a MILLION NickV for your solution to this extremely irritating problem. My computer is back to normal. Again, thank you!!!
August 11, 2009 at 8:49 pm
Awesome….I’ve been trying to resolve IE issues all day. This was right on target.
August 30, 2009 at 10:42 pm
Level 1
3/27/09
After I installed the Google Toolbar with IE8 (the released version), I am getting a data execution prevention notice that says IE 8 must be closed. This happens when I click on a link that is supposed to open in a new tab; e.g., when I hold down the Ctl key while clicking the link. Usually, when I close the error box, the link opens, but in a new IE window, not a new tab in the existing window. On occasion, nothing happens. Then, if I repeat the Ctl click, I may get a new tab, I may get an error message and a new window, and I may get an error message and no new tab or window. I tried using the “turn on DEP except for” IE 8, but with no help.
Uninstalling Google Toolbar for IE 8 seems to have fixed the issue, but now I am left without the Toolbar, which I have come to find essential.
September 7, 2009 at 1:16 pm
Your a genious Nick V!!! I spent all day trying different things before I came across what you did.
Even the microsoft website did’nt help me.
Cheers!
November 9, 2009 at 3:34 pm
Worked like a charm. After reading everyone elses post I did not know it would be that easy!!!!